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Chapter 137 Terminology

Li Ang glanced at Asgard's Heavenly Father in the glass jar and said calmly, "Just as I said before, there are two explanations for the reason why living things are 'aging and dying'.

First, the living organisms automatically evolved into a death mechanism, and second, the living organisms were damaged during their operation.

In view of the first theory, the School Urban Regeneration Medical Department under the leadership of Dr. Strange believes that artificial intervention in the aging process can achieve the goal of delaying the physiological life expectancy limit."

After saying that, he raised his hands, and a healthy shuttle cell projection was suspended above his left hand, and a bloated shuttle cell projection was suspended above his right hand.

"The one on the left is normal cells, and the one on the right is senescent cells."

Li Ang raised two phantoms and asked Thor and others: "Do you see the difference?"

Thor scratched his forehead and carried a hammer to fight to kill the enemy. It was really hard for the Thunder God to identify the cell map.

Instead, Loki raised his hand slightly and said, "There are more damaged DNA in the senescent cells."

"That's right."

Li Ang nodded and said, "According to common sense, multicellular organisms, especially senescent cells in the human body, will be replaced by newborn cells, but over time, senescent cells will begin to occupy the pit and not shit, and will be retained, promoting the aging of multicellular organisms.

This abnormality is because the p53 protein in the human body is shut down.

The P53 gene is a tumor suppressor gene that is located at 17p13.1 of the human chromosome, encoding a 53kD intranuclear phosphorylated protein composed of 393 amino acids, and is called the p53 protein.

It is responsible for cell cycle regulation, DNA repair, cell differentiation, and cell apoptosis.

Once the p53 protein stops, the senescent cells cannot die in a direction, and eventually become congested inside the body, accelerating the aging process of the body."

Speaking of this, Li Ang glanced at the Odin family and found that only Logi and Queen Fleia could understand it, while Thor and Odin were confused.

The queen of the diva Freia can understand it because she is quite studious. After selling herself in the school city, she knows shame and then braves her courage, and absorbs knowledge like a sponge.

And Loji could understand it, because he was injured too deeply in the last "Frost Giant Sexual Chromosome Disorder".

For this god of lies and cunning, she couldn't stand the feeling of knowing nothing and the situation was completely out of her control.

Therefore, while becoming an idol, Loki also made up for genetic biology.

From this point of view, she is many times stronger than a Thor who only likes to think with muscles.

Li Ang smiled and said in a scrupulous manner: "On this basis, Dr. Strange did further research.

They found that it is a transcription factor called FOXO4 that combines with p53, preventing p53 from acting and unable to let senescent cells die.

This FOXO4 transcription factor is quite a domineering presidential meaning and can force p53 to become related to it. The solution is to inject a FOXO4 alternative, FOXO4-DRI short peptide.

This short peptide is D-retro inverso isoform. In simple terms, the L-type amino acid in it is replaced with D-type, and the skeleton direction is also reversed.

FOXO4-DRI short peptide has a higher priority than FOXO4 and is more domineering than domineering presidents. It can deprive FOXO4 of its 'mating right' and prioritize combining with P53 without preventing the latter from continuing to play its role.

From a macroscopic perspective, this short peptide can cause targeted apoptosis of senescent cells, thereby promoting new cells to replace old cells, thereby delaying or even preventing the overall aging process of individual life."

I have to say that the queen of the divine Freia's mind was very fast. She had guessed Li Ang's intentions so she could do it. She said excitedly: "Then if this FOXO4-DRI is injected into Odin's body, his divine body, which is on the verge of aging and collapse, begins metabolism again, destroys old cells, and produces new cells,

My husband doesn’t have to die?!”

As soon as these words were said, not only did Thor's face flash with excitement, but even Odin in the glass cylinder showed a hint of emotional fluctuation.

He just saw through the essence of some things and looked down on the world, not that he wanted to die.

If life spans a minute, or even a month, one year, who would be willing to die?

Unexpectedly, Li Ang shook his head and poured a basin of cold water on the excited Freya and others, "It's not that simple."

FOXO4 - DRI short peptide is just a test product. Even with Ultron's addition, the computing power of the entire scientific research project has been qualitatively improved.

It is just a few transcription factors similar to the effect of this short peptide.

Odin's divine body has long been at its limit. It is similar to the five declines of heaven and man. Every part of his body begins to decay and decay.

If all these transcription factors are tied together, the 'senile cell-targeted apoptosis agent' is directly input into Odin's body, it will only cause the cells in his body to collapse instantly, becoming an ignorant and unconscious cell soup."

Freia and others instantly became depressed. From hope to disappointment, the difference in span between them was too huge.

This is actually Odin himself. If he is not the God King of the Asa tribe, but just an ordinary and ordinary old man on Earth, he can completely rely on the primitive cells of the underground base of the Academy City.

Primitive cells that have long been able to proliferate infinitely can invade the host body, conquer cities and villages between cell tissues, replace most of the host bodies, and allow the host to reach another level of immortality.

However, the powerful divine body of the Asa God clan can block the erosion of primitive cells, making the latter unable to help the former extend his lifespan. It is necessary to rely on the life mechanism in his own body to fight aging.

Just when Freia and others were disappointed and desperate, Li Ang said slowly: "In the first explanation of death of life, the targeted apoptosis agent of senescent cells containing FOXO4-DRI short peptide can indeed play a part of the role.

However, targeted apoptosis agents are like a double-edged sword that will break the dynamic balance of cells in Odin's body.

At this time, we can turn our attention to the second explanation of the death of life."

The second explanation?

Logi and Freia quickly cheered up. According to their lack of understanding of Li Ang, this second explanation is the highlight.

Sure enough, Li Ang said slowly: "The second explanation for the cause of death of a living body is the 'wear principle'.

Free radicals produced during mitochondrial metabolism will destroy DNA, causing abnormal damaged cells to accumulate gradually and form aging.

This is almost an inevitable thing. The thermal movement and routine metabolism in the human body will inevitably lead to the gradual breakage of chemical bonds in proteins.

It is precisely this kind of chemical bond breakage that accumulates more and more necrotic cells and the human body gradually ages.

To put it more professionally, it is that the gradual decrease in molecular fidelity and the gradual increase in molecular disorder have caused changes in molecular structure, resulting in lesions in the overall function of the cell and ultimately aging.
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